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Review Article Volume 14 Issue 3
A comprehensive review on chiral insights and technological breakthroughs in fluoxetine isomer separation using capillary electrophoresis
Sumiya Sharmin Mou, Nasiba Binte Bahar, Sharaf Anjum Shapnil, Jannatul Ferdous, SM Rakibul Hossain, Fatema-Tuz-Zohora, Faisal Ahmed, Muhammad Rakib Al-Mamun, Md Elias Al-Mamun
Received: December 06, 2026 | Published: July 23, 2026
Citation: Mou SS, Bahar NB, Shapnil SA, et al. A comprehensive review on chiral insights and technological breakthroughs in fluoxetine isomer separation using capillary electrophoresis. Pharm Pharmacol Int J. 2026;14(3):85-92. DOI: 10.15406/ppij.2026.14.00499
Abstract
Fluoxetine, a widely prescribed chiral selective serotonin reuptake inhibitor, exists as two enantiomers—S-fluoxetine and R-fluoxetine—that exhibit distinct pharmacological activities. Effective separation of these enantiomers is essential to ensure therapeutic efficacy while minimizing adverse effects. This review critically examines recent advancements in fluoxetine enantioseparation using capillary electrophoresis (CE), with particular emphasis on chiral selector applications, buffer system optimization, and electrophoretic condition modifications that enhance resolution. We highlight the utilization of cyclodextrins, proteins, and ionic liquids as chiral selectors, evaluating their respective mechanisms and performance characteristics. CE offers significant advantages over conventional chromatographic techniques, including superior separation efficiency, rapid analysis times, and minimal sample volume requirements—benefits particularly valuable for analyzing fluoxetine in complex biological and pharmaceutical matrices. This comprehensive synthesis of current methodologies addresses existing knowledge gaps, provides mechanistic insights into chiral recognition, and identifies promising directions for future development, ultimately supporting safer and more effective therapeutic applications of fluoxetine.
Keywords: fluoxetine, enantiomer separation, capillary electrophoresis, chiral selectors, pharmaceutical analysis
©2026 Mou, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.