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Research Article Volume 6 Issue 1
Single and combinatorial herbal formulations reversed hyperglycemia and dyslipidemia in diabetic rats
Chinwendu Maureen Chikezie, Okey Alphonsus Ojiako, Adamma Angela Emejulu, Paul Chidoka Chikezie
Department of Biochemistry, Federal University of Technology, Nigeria
Department of Biochemistry, Imo State University, Nigeria
Received: January 28, 2019 | Published: February 12, 2019
Citation: Chikezie CM, Ojiako OA, Emejulu AA, et al. Single and combinatorial herbal formulations reversed hyperglycemia and dyslipidemia in diabetic rats. J Diabetes Metab Disord Control. 2019;6(1):12-18. DOI: 10.15406/jdmdc.2019.06.00175
Abstract
Background and Objective: Traditional herbs are often administered in form of multi-herbal recipes, which is presumed to exhibit better efficacy than mono-herbal formulations. The current study sought to evaluate the capacities of single herbal formulations (SHFs), double herbal formulations (DHFs), triple herbal formulations (THFs) and quadruple herbal formulation (QHF) of leaf extracts of Acanthus montanus, Asystasia gangetica, Gongronema latifolium and Solanum melongena to reverse hyperglycemia and dyslipidemia in diabetic rats (DM-r). Materials and Methods: Diabetes mellitus (DM) was induced in the rats by single intra-peritoneal (i.p.) injection of 90 mg/kg body weight (b.w.) of alloxan monohydrate in phosphate buffered saline (pH=7.4). The rats with fasting plasma glucose concentration (FPGC) > 110mg/dL for 5 consecutive days were considered diabetic and treated with the herbal formulations for 21 consecutive days. FPGC and serum lipid profile of the rats were measured according to standard methods.
Results: Combined dose (ratio:1:1w/w) of A. gangetica + A. montanus (200mg/kg b.w.) exerted the greatest glycemic control in DM-r, which corresponded to FPBC of 107.2±5.42mg/dL. Additionally, combined doses (ratio: 1:1w/w) of A. gangetica + A. montanus (200mg/kg b.w.) and A. gangetica + G. latifolium (200mg/kg b.w.) substantially reversed dyslipidemia in DM-r.
Conclusion: The present study showed that selected DHFs offered greater glycemic control than other herbal formulations and reversed dyslipidemia in the experimental rat groups. However, all herbal formulations did not offer full therapeutic benefit within the experimental time of 21 days.
Keywords: Diabetes mellitus, dyslipidemia, herbal formulations, hyperglycemia
©2019 Chikezie, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.