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Review Article Volume 17 Issue 3
Nanoformulations in dental and oral healthcare: a comprehensive review of advances from 2020 to 2025
Deepak Prashar
Received: April 20, 2026 | Published: May 29, 2026
Citation: Prashar D. Nanoformulations in dental and oral healthcare: a comprehensive review of advances from 2020 to 2025. J Dent Health Oral Disord Ther. 2026;17(3):67-72. DOI: 10.15406/jdhodt.2026.17.00672
Abstract
Background: Nanotechnology has emerged as a transformative paradigm in dental and oral medicine, offering unprecedented opportunities to improve drug delivery, diagnostics, and biomaterial performance. Nano formulations including polymeric nanoparticles, liposomes, dendrimers, solid lipid nanoparticles, nanogels, and inorganic nanomaterials have demonstrated superior properties over conventional formulations in terms of solubility enhancement, controlled release, mucoadhesion, and targeted delivery to oral tissues. Objective: This review critically appraises the published literature from January 2020 to April 2025, examining the design, formulation strategies, preclinical and clinical outcomes, and safety profiles of nano formulations across key dental disciplines, including caries prevention, periodontology, endodontics, oral oncology, oral mucosal diseases, and implantology. Methods: A systematic search of PubMed, Scopus, Web of Science, and Google Scholar databases was conducted using Medical Subject Headings (MeSH) and free-text terms. Studies were selected based on predefined inclusion and exclusion criteria, focusing on peer-reviewed research articles, randomized controlled trials, systematic reviews, and in vivo/in vitro studies. Conclusion: Nano formulations present a compelling frontier for advancing oral healthcare. However, widespread clinical translation remains hindered by regulatory uncertainties, scale-up difficulties, biocompatibility concerns, and limited long-term clinical data. Future research must prioritize robust randomized trials, standardized characterization protocols, and regulatory frameworks tailored for nanomedicines in dentistry.
Keywords: nanoparticles, dental drug delivery, oral nanomedicine, nano formulation, periodontitis, anti-caries, endodontics
©2026 Prashar. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.