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Research Article Volume 19 Issue 2
SORBS2 and cardiac integrity in COVID-19: a hypothesis on SIRT1-mediated intercalated disc dysfunction
Mosab Nouraldein Mohammed Hamad
Received: March 13, 2026 | Published: April 17, 2026
Citation: Hama MNM. SORBS2 and cardiac integrity in COVID-19: a hypothesis on SIRT1-mediated intercalated disc dysfunction. J Cardiol Curr Res. 2026;19(2):55-56. DOI: 10.15406/jccr.2026.19.00642
Abstract
SORBS2 (Sorbin and SH3 domain-containing protein 2), also known as ArgBP2, is a cytoskeletal adaptor protein essential for maintaining cardiac structural integrity and electrical coordination through its localization at intercalated discs (IDs). While COVID-19- associated cardiac complications are frequently attributed to inflammation and direct viral effects, the role of structural protein degradation remains underexplored. This manuscript proposes a mechanistic framework wherein the inactivation of Sirtuin 1 (SIRT1), a critical cardioprotective protein—leads to a secondary dysfunction of SORBS2. This cascade disrupts intercalated disc integrity, contributing to the arrhythmias and ventricular dysfunction observed in severe COVID-19 cases. We further consider a speculative role for genomic instability as a contributing factor in long-term myocardial instability.
Keywords: SORBS2, SIRT1, intercalated discs, COVID-19, arrhythmogenic cardiomyopathy, myocardial dysfunction
©2026 Hama. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.