The use of stem cells in regenerative medicine was initially promoted as a means of treating illnesses due to the functional lack of specific types of specialized cells. Stem cells were further seen as a way to i) replace defective organs with better performing organs, such as the heart, ii) restore diminished brain functions, iii) replace lost limbs, and iv) boost the body’s defenses against both cancer and infectious diseases. The early reliance on using primitive embryonic cells for stem cell therapy was offset by showing that differentiated cells from an adult could be genetically reprogrammed to become replicating progenitor cells, which could then either naturally or genetically be transformed into multiple types of specialized cells. The clinical application of cell modifying technologies has been relatively slow, however, mainly due to lingering safety concerns regarding the possibility of the cells forming cancers. There are fewer safety concerns with the use of cells from umbilical cord blood (UCB) and from adipose tissue, which have retained the capacity to mature into different cell types. These mesenchymal stem cells (MSC) are currently being used in the empirical treatment of multiple clinical conditions. Their mode of action, however, is not that of replacing absent or diseased cells in the body, but rather it is the release of compounds able to i) suppress inflammation and ii) promote the regeneration of cells already existing within the body. An alternative cellular energy (ACE) pathway has been described as a source of cellular energy that is different from the energy obtained from food metabolism. It is expressed as an added dynamic or kinetic quality of the body’s fluids. It results from the absorption of an external energy termed KELEA (kinetic energy limiting electrostatic attraction). The ACE pathway can be enhanced using KELEA activated water products. One such waterceuticalÔ, called EnercelÔ, was originally regarded as a homeopathic remedy. In preliminary clinical studies, Enercel is showing similar benefits as those ascribed to the injection of MSC or of their derived compounds. Waterceutical products, such as Enercel, are simpler, safer and more effective potential alternatives to the in vivo injections of MSC or MSC-derived compounds. An additional advantage is that certain KELEA activated fluids can support the ACE pathway, even when placed at or near the skin surface. Further clinical benefits can be expected when waterceuticals are used in conjunction with other means of enhancing the body’s ACE pathway. Some of these additional therapeutic methods are discussed in this paper.

Keywords: enercelÔ, enerceuticalÔ, waterceuticalÔ, stem, KELEA, ACE, iPSC

HSC, hematopoietic stem cells; ESC, embryonic stem cells; UCB, umbilical cord blood; MSC, mesenchymal stem cells; SVF, stromal vascular fraction; Ipsc, induced pluripotent stem cells; PRP, platelet rich plasma; ACE, alternative cellular energy; KELEA, kinetic energy limiting electrostatic attraction; CSC, copper-silver-citrate

The original intent of stem cell therapies was to provide patients with undifferentiated cells that could differentiate in to the specific types of specialized cells, which were either absent or dysfunctional in the patients.¹ Basically, the stem cells were intended to replenish the body with a fresh source of specific types of normally functioning cells. This goal clearly applied to the grafting of bone marrow cells into leukemia patients after the patients received radiation or chemotherapy.² Ideally, the donors of the bone marrow derived hematopoietic stem cells (HSC) are genetically closely related to the individual recipients of the donor cells to minimize possible graft-versus-host and host-versus-graft immunological reactions.³ Replicating cells obtained from very early embryos are naturally destined to generate progeny cells that can collectively differentiate into all types of specialized cells.^4,5 These very primitive replicating cells, however, retain the potential of developing into a teratoma and other tumors. There is a requirement, therefore, to somewhat genetically restrict these cells before they are clinically used as pluripotent embryonic stem cells (ESC).⁶ There is also an ethical issue in sacrificing human embryos as the source of therapeutic cells. This latter concern has been avoided by showing that cellular differentiation is a reversible process. Thus, mature cells obtained from an adult can be induced by genetic reprogramming into a more primitive or embryonic cell type.⁷ As with ESC, these induced pluripotent stem cells (iPSC), also have to be genetically restricted from potentially becoming tumors. Methods for reliably achieving this safety goal for primitive stem cells are not convincingly proven and this has delayed progress in the common use of iPSC. This barrier has not, however, prevented the extensive use of therapeutic cells other than ESC and iPSC.

The focus of stem cell research has largely switched to the use of developing cells, which have undergone sufficient maturation to not be a threat of developing into tumors. Such developing cells canstillreta in the progenitor cell capacities ofboth replicating and transforming into more highly specialized cells. In addition to HSC, bone marrow also contains progenitor cells able to differentiate in tissue cultures into non-hematopoietic cells.⁸ Umbilical cord blood (UCB)from newborns similarly contain cells that can transform into a limited variety of non-hematopoietic cell types.⁹ Related multipotential, progenitor cells can also be derived from the amnion¹⁰ and the placenta.¹¹ Although, the progeny cell types obtainable from birth-derived progenitor cells are not as diverse as the cell types derived from ESC or iPSC, they are, nevertheless, still referred to as stem cells. Except in circumstances in which cord blood has been stored at birth for future possible use by the donor, the newborn-derived cells are histoincompatible with the host. In the absence of immunosuppressant these cells would not be expected to indefinitely survive within the recipient.

Liposuction-harvested fat tissue is also a source of partially differentiated progenitor cells^12–15 referred to as mesenchymal stem cells (MSC). These cells are capable of differentiating not only into fat cells (adipocytes) but also into several other cell types. MSC in liposuction-obtained fat tissue can be selectively concentrated by centrifugation into a stromal vascular fraction (SVF)and may be further modified in tissue culture.^16–18 In most patients, however, the fat tissue is not fractionated or cultured, but istransferreddirectly into the site of disease and/or injected intravenously. Relocating fat cells between tissue sites has been performed by plastic surgeons for a number of years in various cosmetic procedures.¹⁹ The transferred cells can potentially survive since there is no histocompatibility barrier when the cells are transferred between fat tissue sites in the same individual. Even so, some cosmetic plastic surgeons commonly delay reinjecting the fat tissue (personal communication). In the intervening period, the cells are stored in a freezer leading to a loss of the cells’ viability. Successful cosmetic results are seemingly still obtainable using non-viable cells. The actual demonstration of persisting fat tissue-derived MSC or of their progeny in tissues of the recipients is lacking. Moreover, the overall clinical results using MSC available from histoincompatiblenewbornsand from histocompatibleadult adipose tissue or bone marrow are generally comparable, with, if anything, better overall success occurring with UCB cells from newborn infants.

It is estimated that there are now over 600 stem clinics within the United States and many additional centers elsewhere in the world. These centers primarily offer UCB cells or adipose tissue-derived MSC as therapy for a wide variety of conditions. These include improving facial appearance, hair growth, traumatic joint damage, rheumatoid and osteoarthritis, spinal cord injuries, acute burns, autoimmune diseases, autism, pain syndromes, neurodegenerative illnesses, and cancer.^20–30 Even relatively simple procedures are typically priced in excess of $10,000, with no current coverage by medical insurance. Unfortunately, such commercial gains have dulled much of the critical reasoning regarding the use of stem cells and have raised questions regarding the objective assessments of clinical outcomes. In particular reports of fat embolism appear to be underplayed,³¹ as well as blindness from intraocular fat cell injections.³² It has also been suggested that some types of MSC can actually promote the growth of nascent tumor cells.^33–35

Also entering into the commercial arena are dietary supplements, which are promoted as being especially nourishing for stem cells or as being able to better mobilize stem cells for delivery to damaged tissues.³⁶ Several of these supplements comprise the same or similar herbal products, which were previously marketed as anti-oxidants. The anti-oxidant activity is an indirect indication that the products have available regions of separated electrical charges and are, therefore, dipolar. The significance of this statement is addressed below.

As stated above, there is no evidence of long-term persistence of either UCB cells or fat-derived MSC in the recipients. This is especially apparent when the cells are inoculated into peripheral tissues, such as joints. Although, not widely discussed, the more reasonable view is that the injected cells release a variety of compounds that can apparently assist in suppressing symptoms and in repairing locally damaged tissues. These compounds or factors apparently act directly on the body’s preexisting cells in a process referred to as a paracrine effect.³⁷ The paracrine mode of action is fundamentally different from what was initially viewed as the primary mode of action of stem cells. Rather, the apparent benefits of inoculated stem cells are more directly comparable to the earlier uses of fetal tissue extracts as a rejuvenating therapy.³⁸ A number of sub cellular components released from cultured stem cells(secretome) have been characterized. They can be in the form of cell-derived particles called exomes,^39,40 or comprise soluble mediators, including cytokines.⁴¹ These materials can be directly injected into patients as alternatives to using viable cells. There is overlap in the biological benefits of compounds derived from stem cells with those reported as occurring with compounds present in autologous platelet rich plasma (PRP)^42,43 and with on-autologous extracts from amniotic fluids.^44,45 The major biological functions of these various compounds are typically described asi) suppressing tissue damaging inflammation, and/orii) promoting the growth of regenerating normal tissues. These two actions are similarly achievable via the proposed paracrine effects of inoculated stem cells, without the cells becoming engrafted into the recipient’s tissues.

Without the fanfare of stem cell therapy, there are several studies indicating that disease suppression and tissue regeneration can be achieved using energy-based therapies. The beneficial effects of these therapies can be explained in terms of the body having an alternative cellular energy (ACE) pathway. Thus, I have proposed that this pathway is type of cellular energy, which is fundamentally different from the cellular energy obtained from the metabolism of food.^46–56 The ACE pathway is reflected in an added dynamic (kinetic) quality of the body’s fluids. It arises from an external force termed KELEA (kinetic energy limiting electrostatic attraction), which can enter into the body using three basic mechanisms. The first is assumed to be a natural antenna function of the oscillating electrical activity of the brain and possibly muscles, including the heart.⁵⁷ Certain modes of the brain’s electrical oscillations are likely to be more efficient than others, presumably with some level of conscious regulation. Second; this proposed human antenna function can also be enhanced by increasing the environmental levels of KELEA to which the individual is exposed.^58,59 This is achievable using devices that are driven by either oscillating electrical currents or by converging electromagnetic radiations, including light. The third and best documented method of enhancing the ACE pathway is the use of KELEA activated water or water activating compounds. Water and other fluids can be reliably activated using various dipolar compounds that are capable of attracting KELEA into fluids.^60–64 Once the water is sufficiently activated, the activating compounds, referred to as enerceuticalsÔ, can be removed by repeated dilutions, filtration, decanting or other means. KELEA activated water can also be produced by sufficient exposure to an increased environmental level of KELEA as created using various devices. The natural water in certain locations in the world is intrinsically activated.⁴⁶ Depending upon how it is prepared and stored, the levels of KELEA activation can range from being minimal to being substantial. Highly activated water will retain its activation over a long period time if stored in a sealed container. Moreover, it can attract additional KELEA, which is transferrable to ordinary water that is placed close by to the highly activated water.

A well-tested waterceuticalproduct that is suitable for direct injection into humans is presently available. It is called Enercel and produced by World Health Advanced Technology, with its head office in Sarasota, FL. It was initially characterized as a homeopathic remedy related to an Argentinian product called HANSI (homeopathic activator of the natural system immune). The activating enerceuticals mainly comprise small amounts of various herbal tinctures plus some minerals. The concentrations of these compounds are further reduced by a factor of 1:10,000 using repeated 10-fold dilutions, each dilution being followed by succussion (jolting). Succussion is also used prior to the administration of Enercel formulations, which are available for intramuscular, intravenous, intraarticular, intranasal and/or inhalational administration. A slightly different formulation is also available for direct topical use on the skin.

Intravenous administered Enercelreduces HIV levels in AIDS patients.⁶⁵ There is an accompanying markedly improved sense of wellbeing. Inhalation of Enercel, as an additional therapy, cleared mycobacteria from the sputum in tuberculosis infected AIDS patients.⁶⁵ Enercel has also lead to the painless regression of cancers, presumably by providing sufficient cellular energy for tumor cell apoptosis.^66,67 The severity of tropical diarrhea in children was significantly lessened using two intramuscular injections of Enercel.⁶⁸

Enercel and another KELEA activated waterceutical prepared using copper-silver-citrate (CSC) complexes werealso remarkably successful in achieving one or more of the following: Scar-free healing of acute burns; regeneration of ischemic limb tissues; healing of infected wounds; and the repair of a traumatic penetrating injury.⁶⁹ Intraperitoneal administration of the CSC solution dramatically prevented surgical adhesions from forming after a cesarean section was performed in a goat, with additional overall improvement in the health of the animal.⁶⁹ Following intraarticular injections, relatively small amounts (<1ml) of another waterceutical product promptly relieved arthritic pain in several treated humans and animals (unpublished).

A reasonable inference from these observations is that many of the current stem cell-based therapies will likely be equally if not more achievable through the direct administration of pharmaceutical grade KELEA activated solutions. One area for directly comparing the benefits of stem cells with waterceutical products is in the treatment of acute burns. Enercel has completely prevented scar tissue from forming at a burn sites when it was applied shortly after a second to third-degree burn. A major advantage of waterceuticals for parental use is that essentially all of the water activating compounds can be removed prior to their administration. Depending upon the type of enerceuticals used, this can be achieved by repeated dilutions, decanting, or zero-residue filtration. The absence of detectable compounds in the water will help avoid many of the FDA regulatory requirements that are currently associated with the use of stem cells and/or stem cell products.^70–78 There should be even less regulatory concerns with the use of water activating devices that function by increasing the available environmental levels of KELEA.

Formal clinical research studies will require the direct comparison of KELEA related fluids with regular pharmaceutical grade fluids, administered in the absence of any additional treatments. For more routine care, a combination of various ACE-pathway enhancing methods can be utilized. A sustainable improvement in the ACE pathway is potentially achievable through efforts to optimize the proposed KELEA antenna function of the brain through appropriate training and education. Efficient food metabolism can also be addressed. It is interesting to note that some of the major stem cell clinics are also incorporating positive psychology, nutrition and lifestyle changes into their programs. This approach follows the suggestion that the stem cells are analogous to seeds, but that they still require a healthy soil in the form of an improved body’s terrain to thrive. This type of reasoning falsely assumes long-term persistence of the stem cells. A simpler explanation is that the diet and lifestyle changes are conducive to a better ACE pathway.

The current wave of interest in mesenchymal stem cell (MSC) therapy may lead to a better understanding of the alternative cellular energy (ACE) pathway. This is especially relevantsince the primary beneficial effects of MSC and their products may well be mediated via the ACE pathway. The premise of this article is that injections of pharmaceutical grade waterceuticalswillachieve similar if not superior benefits to those occurring through the use of MSC. Enercel is a clinically tested waterceutical for parental administration. It can be directly compared with injected MSC in the therapy of diverse clinical illnesses. If the outcomes are comparable, the use of Enerceland other waterceuticals will be far less expensive than using stem cells and will certainly face fewer regulatory burdens. Waterceuticals are also suitable for regular ingestion, inhalation or direct application to the skin. The practical clinical uses of waterceuticals can logically be coupled with other therapeutic approaches to enhance the ACE pathway.

The University of Quantum Dynamics (UQD) is a coalition of entities, including the Institute of Progressive Medicine, a component of MI Hope Inc., a non-profit public charity. UQD is dedicated to establishing a role for energy-based medicine in routine medical care, including patient directed self care. UQD current programs include REACH (Regenerative Energy Assisted Clinical Healing). The author is particularly thankful to Dr. David Christner, CEO of World Health Advanced Technologies, for providing unpublished clinical data on Enercel and for many fruitful discussions.

The author declares no conflict of interest.

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