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Mini Review Volume 6 Issue 5
Mesenchymal stem cell therapy for autoimmune diseases: future Perspectives
Giuseppina Pennesi
Area Vasta 4 Fermo-ASUR Marche, Italy
Area Vasta 4 Fermo-ASUR Marche, Italy
Received: January 01, 1971 | Published: November 16, 2018
Citation: Pennesi G. Mesenchymal stem cell therapy for autoimmune diseases: future Perspectives. Int Clin Pathol J. 2018;6(6):183–184. DOI: 10.15406/icpjl.2018.06.00185
Abstract
Mesenchymal Stem Cells (MSC) transplanted into a recipient organism for therapeutic purposes exert their action not only by cell-to-cell contact, but also by secreting soluble factors. Since biological issues and regulatory constrains hamper the use of MSC for clinical purposes, novel approaches should be attempted. In the last years, the feasibility of using MSC-derived micro vesicles as potential mediators carrying tolerogenic molecules has been tested in pre-clinical modes of autoimmune diseases.
Keywords: mesenchymal stem cells, exosome, microvescicles, integrins, selectins, metalloproteinases, autoimmunity, cell therapy, osteoblasts, protein, tetraspanins, bodies, multivesicular, adipocytes, chondroblasts, immunosuppressant, regenerative
©2018 Pennesi. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.