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Research Article Volume 8 Issue 1
Effect of yeast purified β-glucan in experimental treatment of pythiosis in rabbits
Janio Morais Santurio, Sydney Hartz Alves, Daniela Isabel Brayer Pereira, Vaclav Vetvicka, Carlos AF de Oliveira
Received: April 08, 2020 | Published: April 16, 2020
Citation: Santurio JM, Alves SH, Pereira DIB, et al. Effect of yeast purified ?-glucan in experimental treatment of pythiosis in rabbits. Int Clin Pathol J. 2020;8(1):14-20. DOI: 10.15406/icpjl.2020.08.00199
Abstract
Purified β-1,3-1,6-glucan derived from the cell wall of yeast has important biological properties and is considered to be a potent immunomodulatory compound. Pythium insidiosum is an aquatic oomycete affecting mammals and causing infections of unfavorable prognosis. Treatment is difficult, and therapeutic options commonly include surgery, immunotherapy, and antimicrobial agents. This study evaluated the clinical effects and antioxidant activity of yeast-purified β-glucan in the treatment of experimental pythiosis in rabbits. The disease was induced in 30 rabbits and we compared the effects of food supplementation with β-glucan with oral treatment with a combination of antifungals. Results suggested that the β-glucan showed antioxidant, immunomodulatory, and antiinflammatory effects. Although there has not been a clinical cure of the treated animals, it appears that the inclusion of the β-glucan is beneficial as an adjuvant to the treatment of pythiosis via strengthening of nonspecific immunity and improvement of antioxidant status of the animal.
Keywords: immunotherapy, glucans, pythiosis, rabbi
©2020 Santurio, et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and build upon your work non-commercially.